Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies.

@article{Gladstone2013PartiallyMT,
  title={Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies.},
  author={Douglas E Gladstone and Andrea A. Zachary and Ephraim Joseph Fuchs and Leo Luznik and Yvette L. Kasamon and Karen E. King and Robert A Brodsky and Richard M. Jones and Mary S. Leffell},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2013},
  volume={19 4},
  pages={647-52}
}
The presence of donor human leukocyte antigen (HLA)-specific antibodies (DSA) increases engraftment failure risk in partially HLA-mismatched, or HLA-haploidentical, allogeneic marrow (alloBMT) transplantation. As pre-existing sensitization to HLA antigens is not well characterized among candidates for HLA-haploidentical alloBMT, we retrospectively evaluated both the incidence and relative strength of DSA in this patient population. Based on correlations of solid-phase antibody assays on the… CONTINUE READING