Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium-induced colitis in mice.

@article{Naito2006PartiallyHG,
  title={Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium-induced colitis in mice.},
  author={Yuji Naito and Tomohisa Takagi and Kazuhiro Katada and Kazuhiko Uchiyama and Masaaki Kuroda and Satoshi Kokura and Hiroshi Ichikawa and Junko Watabe and Norimasa Yoshida and Takeshi Okanoue and Toshikazu Yoshikawa},
  journal={The Journal of nutritional biochemistry},
  year={2006},
  volume={17 6},
  pages={402-9}
}
Partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber produced by a controlled partial enzymatic hydrolysis of guar gum beans, has various physiological actions. The aim of the present study was to elucidate the beneficial effects of PHGG on colonic mucosal damage and on the inflammatory response in a dextran sulfate sodium (DSS) colitis model. After 2 weeks of prefeeding of PHGG, acute colitis was induced with 8% DSS in female BALB/c mice. Colonic mucosal inflammation was… CONTINUE READING

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