Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin

@inproceedings{NikitorowiczBuniak2015PartiallyEE,
  title={Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin},
  author={Joanna Nikitorowicz-Buniak and Christopher P. Denton and David Abraham and Richard Stratton and Carol Feghali-Bostwick},
  booktitle={PloS one},
  year={2015}
}
The origin of myofibroblasts in fibrotic conditions remains unknown and in systemic sclerosis (SSc) it has been proposed that activation of local fibroblasts, trans-differentiation of perivascular or vascular cells, recruitment of fibrocyte progenitors, or epithelial to mesenchymal transition (EMT) could be contributing. Data from our laboratory indicate that the epidermis in scleroderma is activated with the keratinocytes exhibiting a phenotype normally associated with tissue repair, including… CONTINUE READING
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Molecular mechanisms of epithelial–mesenchymal transition

Nature Reviews Molecular Cell Biology • 2014
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