Partial reversal of the effect of maternal care on cognitive function through environmental enrichment

@article{Bredy2003PartialRO,
  title={Partial reversal of the effect of maternal care on cognitive function through environmental enrichment},
  author={Timothy W. Bredy and Richard Humpartzoomian and Donald Peter Cain and Michael J. Meaney},
  journal={Neuroscience},
  year={2003},
  volume={118},
  pages={571-576}
}
Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression
TLDR
Findings suggest that environmental enrichment reverses the effects of reduced maternal care through the same genomic target, the NR2B gene, and possibly effects on other subunits of the NMDA and AMPA receptors.
Intensification of maternal care by double‐mothering boosts cognitive function and hippocampal morphology in the adult offspring
TLDR
It is demonstrated that double‐mothering exerts a long‐term positive control on cognitive function and hippocampal neuronal connectivity and might offer a concrete possibility to limit or reverse the consequences of negative predisposing conditions for normal cognitive development.
Maternal care influences neuronal survival in the hippocampus of the rat
TLDR
The findings suggest an influence of maternal care on neuronal survival in the hippocampus, and emphasize the importance of early maternal care for hippocampal development.
Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress
TLDR
It is suggested that maternal effects may modulate optimal cognitive functioning in environments varying in demand in later life, with offspring of high and low LG mothers showing enhanced learning under contexts of low and high stress, respectively.
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood.
  • I. Weaver, M. Meaney, M. Szyf
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
It is reported that TSA and methionine treatment reversed the effect of maternal care on open-field behavior, and >900 genes stably regulated by maternal care were identified.
Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty.
TLDR
Maternal LG and the neural mechanisms that regulate this behavior exhibited a high degree of plasticity in response to changes in environment both within and beyond the postnatal period, with implications for the transmission of behavioral response to novelty and maternal care across generations.
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