Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin.

@article{Desaphy1998PartialRO,
  title={Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin.},
  author={Jean-François Desaphy and Annamaria De Luca and Sabata Pierno and P Imbrici and Diana Conte Camerino},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 2},
  pages={
          903-12
        }
}
This study was aimed at investigating the effects of chronic treatment of aged rats with growth hormone (GH, 8 weeks) or the GH-secretagogue hexarelin (4 weeks) on the biophysical modifications that voltage-gated sodium channels of skeletal muscle undergo during aging, by means of the patch-clamp technique applied to fast-twitch muscle fibers. Two phenotypes of aged-rat fibers could be discriminated on the basis of channel conductance. In the young phenotype, sodium channels present a… CONTINUE READING

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