[Partial purification of endogenous inhibitors of (+)-[3H] SKF 10047 binding with sigma-opioid receptors of the liver].

Abstract

Porcine liver extract inhibits (+)-[3H]SKF 10047 binding to rat liver membranes. The inhibitors of (+)-[3H]SKF 10047 binding were detected in acetone supernatant and in acid acetonated powder of the liver extract. Partial purification of the acetone supernatant revealed some characteristics of these inhibitors: low molecular weight (less than 1000), thermostability, resistance to pronase digestion, solubility in water and organic solvents.

Cite this paper

@article{Nagornaia1988PartialPO, title={[Partial purification of endogenous inhibitors of (+)-[3H] SKF 10047 binding with sigma-opioid receptors of the liver].}, author={L V Nagornaia and Nelya N. Samovilova and N. V. Korobov and V. A. Vinogradov}, journal={Biulleten' eksperimental'noĭ biologii i meditsiny}, year={1988}, volume={106 9}, pages={314-7} }