Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.

@article{karydov2009PartialPA,
  title={Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.},
  author={Lucie {\vS}karydov{\'a} and Adam Skarka and Romana Novotn{\'a} and Lucie Zivn{\'a} and H Martin and Vladim{\'i}r Ws{\'o}l and Edmund Maser},
  journal={Toxicology},
  year={2009},
  volume={264 1-2},
  pages={52-60}
}
Carbonyl reducing enzymes play important roles in the biotransformation and detoxification of endo- and xenobiotics. They are grouped into two protein superfamilies, the short-chain dehydrogenases (SDR) and aldo-keto reductases (AKR), and usually are present in the cytoplasm of a cell. So far, only one membraneous carbonyl reductase has been described, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which is located in the endoplasmic reticulum and which significantly contributes to… CONTINUE READING