Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice

@article{Tabatabaei1992PartialPE,
  title={Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice},
  author={A H Alaei Tabatabaei and Sr. Thomas L. Perry and Shirley M. Hansen and Charles John Krieger},
  journal={Neuroscience Letters},
  year={1992},
  volume={141},
  pages={192-194}
}
The protective effect of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced reduction of striatal dopamine (DA) was examined in C57 BL/6 mice. Striatal DA levels were significantly higher in animals receiving parenteral MK-801 before and for 48 h following MPTP administration after 28 days than in animals receiving MPTP alone. The effect was not due to inhibition of monoamine oxidase-B (MAO-B) by MK-801. These data suggest… CONTINUE READING
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