Partial prevention of procarbazine induced germinal cell aplasia in rats by sequential GnRH antagonist and testosterone administration.

@article{Pogach1988PartialPO,
  title={Partial prevention of procarbazine induced germinal cell aplasia in rats by sequential GnRH antagonist and testosterone administration.},
  author={Leonard M Pogach and Y. Lee and Sarah Gould and William Giglio and Hosea F. S. Huang},
  journal={Cancer research},
  year={1988},
  volume={48 15},
  pages={4354-60}
}
The present study examined the feasibility of using a combination of gonadotropin releasing hormone antagonist (GnRH-A) and testosterone in the prevention of procarbazine induced germinal aplasia. Daily injections of GnRH-A or vehicle were given to adult male rats for 21 days prior to procarbazine (PCB) administration and continued until 2 days after the second of two doses of procarbazine (200 mg/kg i.p.) given 1 week apart. One group of rats receiving GnRH-A and PCB was given s.c. two 5-cm… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Specific differences in the sensitivity to the antitesticular effects of (Acon April 19, 2017

K. Sundaram, F. Schmidt, +3 authors C. W. Bardin
Morphological pattern Contraception, • 1988

Protective effects of analogs of luteinizing hormone-releasing hormone against x-radiation-induced testicular damage in rats.

Proceedings of the National Academy of Sciences of the United States of America • 1987
View 1 Excerpt

Effect of GnRH antagonist administration upon spermatogenesis in Sprague Dawley rats (Abstract)

L. Pogach, H.F.S. Huang, Y. Lee, W. Giglio
67th Endocrine Society, • 1985
View 1 Excerpt

Effects of luteinizing hormone releasing hormone agonist given during combination chemotherapy on posttherapy fertility in male patients with lymphoma: preliminary observations

D. H. Johnson, R. Line, +6 authors A. Greco
Blood • 1985
View 2 Excerpts

GnRH agonist treatment and cyclophosphamide-induced testicular cytotoxicity (Abstract)

M. F. daCunha, M. L. Meistrich, S. Nader
J. Androl., • 1985
View 1 Excerpt

A rat model for ,

S. F. Gould, D. Powell, T. Nett, L. M. Glode
Arch. Androl. • 1983
View 2 Excerpts

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