Partial neuroprotection by 17-β-estradiol in neonatal γ-irradiated rat cerebellum.

  title={Partial neuroprotection by 17-β-estradiol in neonatal γ-irradiated rat cerebellum.},
  author={Mar{\'i}a Aurelia Zorrilla Zubilete and Laura Ruth Guelman and Dami{\'a}n G Maur and Lucila Guadalupe Caceres and Hugo R{\'i}os and Luis Mar{\'i}a Zieher and Ana Mar{\'i}a Genaro},
  journal={Neurochemistry international},
  volume={58 3},
Acute and long-term complications can occur in patients receiving radiation therapy. It has been suggested that cytoprotection might decrease the incidence and severity of therapy-related toxicity in these patients. Developing cerebellum is highly radiosensitive and for that reason it is a useful structure to test potential neuroprotective substances to prevent radiation induced abnormalities. Recent studies have shown that estrogen can rapidly modulate intracellular signalling pathways… CONTINUE READING


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