Partial nephrectomy and furosemide in toxic and ischemic nonoliguric acute renal failure in rats

@article{Middeke1985PartialNA,
  title={Partial nephrectomy and furosemide in toxic and ischemic nonoliguric acute renal failure in rats},
  author={Martin Middeke and Gustav Drasch and Heinrich Holzgreve},
  journal={Research in Experimental Medicine},
  year={1985},
  volume={185},
  pages={227-232}
}
SummaryReduction of the renal mass causes similar tubulo-dynamic changes as furosemide, e.g., hyperperfusion of the single nephron. Therefore, the effect of 5/6 nephrectomy (NX) and furosemide (F) either alone or in combination was evaluated in nonoliguric acute renal failure, using two toxic (glycerol and HgCl2) and one ischemic model.In the HgCl2 model, NX and F alone had a protective effect on whole kidney function, e.g., the increase in serum creatinine was smaller as compared to control… CONTINUE READING