Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits

@article{BraydaBruno2013PartialLI,
  title={Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits},
  author={Laurent Brayda-Bruno and Nicole Mons and Benjamin K. Yee and Jacques Micheau and Aline Marighetto},
  journal={Neurobiology of Disease},
  year={2013},
  volume={54},
  pages={372-381}
}
The functional relevance of septo-hippocampal cholinergic (SHC) degeneration to the degradation of hippocampus-dependent declarative memory (DM) in aging and Alzheimer's disease (AD) remains ill-defined. Specifically, selective SHC lesions often fail to induce overt memory impairments in animal models. In spite of apparent normal performance, however, neuronal activity within relevant brain structures might be altered by SHC disruption. We hypothesized that partial SHC degeneration may… CONTINUE READING
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