Partial ischemia reduces the efficiency of sarcoplasmic reticulum Ca2+ transport in rat EDL

@article{Tupling2001PartialIR,
  title={Partial ischemia reduces the efficiency of sarcoplasmic reticulum Ca2+ transport in rat EDL},
  author={Russell Tupling and Howard Green and Susan Tupling},
  journal={Molecular and Cellular Biochemistry},
  year={2001},
  volume={224},
  pages={91-102}
}
To investigate the hypothesis that prolonged partial ischemia would result in a depression in homogenate sarcoplasmic reticulum (SR) Ca2+-sequestering and mechanical properties in muscle, a cuff was placed around the hindlimb of 8 adult Sprague–Dawley rats (267 ± 5.8 g; × ± S.E.) and partially inflated (315 mm Hg) for 2 h. Following occlusion, the EDL was sampled both from the ischemic (I) and contralateral control (C) leg and SR properties compared with the EDL muscles extracted from rats (n… CONTINUE READING
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