Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice.

@article{Frstenberger1985PartialIO,
  title={Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice.},
  author={Gerhard F{\"u}rstenberger and Volker Kinzel and Markus Schwarz and Friedrich Marks},
  journal={Science},
  year={1985},
  volume={230 4721},
  pages={76-8}
}
Alterations in NMRI mouse skin induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in "stage I of tumor promotion" are slowly reversible, and this reversibility has a half-time of 10 to 12 weeks. The tumor response observed in the course of an initiation-promotion experiment in vivo is independent of whether stage I of promotion occurs before or after initiation. Since the time interval between treatment with the promoter, and subsequent initiation can be extended up to at least 6… CONTINUE READING

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