Partial inhibition of protein synthesis accelerates the synthesis of porphyrin in heme-deficient mutants of Escherichia coli

@article{Nakayashiki2004PartialIO,
  title={Partial inhibition of protein synthesis accelerates the synthesis of porphyrin in heme-deficient mutants of Escherichia coli},
  author={T. Nakayashiki and K. Nishimura and R. Tanaka and H. Inokuchi},
  journal={Molecular and General Genetics MGG},
  year={2004},
  volume={249},
  pages={139-146}
}
Mutants of Escherichia coli defective in the HemA protein grow extremely poorly as the result of heme deficiency. A novel hemA mutant was identified whose rate of growth was dramatically enhanced by addition to the medium of low concentrations of translational inhibitors, such as chloramphenicol and tetracycline. This mutant (H110) carries mutation at position 314 in the hemA gene, which resulted in diminished activity of the encoded protein. Restoration of growth of H110 upon addition of the… Expand
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