Partial hippocampal pyramidal cell loss alters behavior in rats: implications for an animal model of schizophrenia.

@article{Port1991PartialHP,
  title={Partial hippocampal pyramidal cell loss alters behavior in rats: implications for an animal model of schizophrenia.},
  author={Robert Port and J A Sample and Kevin S. Seybold},
  journal={Brain research bulletin},
  year={1991},
  volume={26 6},
  pages={993-6}
}
A putative biological substrate of schizophrenia involves cellular pathology within the hippocampus. While hippocampal dysfunction is associated with impaired learning and memory, schizophrenics have been observed to acquire simple conditioned reflexes at rates superior to controls. The present study evaluates the acquisition of shuttlebox avoidance responses in animals with partial damage to hippocampus. Intraventricular microinjections of kainic acid (0.5 or 1.5 nM) were utilized to partially… CONTINUE READING

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