Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures

  title={Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures},
  author={James S. Sutcliffe and Michael K Han and Taneem Amin and Robert A Kesterson and Erika L Nurmi},
  journal={BMC Genomics},
  pages={15 - 15}
Chromosomal abnormalities affecting human chromosome 15q11-q13 underlie multiple genomic disorders caused by deletion, duplication and triplication of intervals in this region. These events are mediated by highly homologous segments of DNA, or duplicons, that facilitate mispairing and unequal cross-over in meiosis. The gene encoding an amyloid precursor protein-binding protein (APBA2) was previously mapped to the distal portion of the interval commonly deleted in Prader-Willi and Angelman… CONTINUE READING


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