Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan

@article{Lin2007PartialDA,
  title={Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan},
  author={Yi-Wen Lin and Lea Chia‐Ling Hsu and P. Kuo and William J. Huang and H. Chiang and S. Yeh and T. Hsu and Y. Yu and Kuang-Nan Hsiao and R. Cantor and P. Yen},
  journal={Human Mutation},
  year={2007},
  volume={28}
}
The Azoospermia Factor c (AZFc) region on the Y chromosome long arm is one of the least stable regions in the human genome. It consists almost entirely of very long repeats and is prone to rearrangement. Numerous structures at AZFc have been identified, and some of them have been reported to be associated with male infertility. We screened 580 Han Chinese in Taiwan for AZFc deletion and duplication using three PCR assays, and characterized the DAZ genes in selected subjects with additional… Expand
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