Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.

@article{Coward1990PartialDA,
  title={Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.},
  author={David M. Coward and Alistair Kerr Dixon and Stephan Urwyler and Tasha Gibson White and Albert Enz and Manfred Karobath and Gary Terence Shearman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={252 1},
  pages={
          279-85
        }
}
The aminoergolines SDZ 208-911 [N-[(8-alpha)-2,6-dimethylergoline-8-yl]-2,2- dimethylpropanamide] and SDZ 208-912 [N-[8-alpha)-2-chloro-6-methylergoline-8-yl]- 2,2-dimethylpropanamide] exhibit nonclassical, neuroleptic-like properties in rodents. Thus, they are equipotent to haloperidol as inhibitors of apomorphine-induced gnawing behavior and conditioned avoidance responding, but are essentially devoid of cataleptogenic activity. In addition, they show high affinity for central D-2 receptors… CONTINUE READING

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