Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin.

@article{Schrder2008PartialDO,
  title={Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin.},
  author={Peter Schr{\"o}der and Tobias Gremmel and Mark Berneburg and Jean Krutmann},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 9},
  pages={2297-303}
}
In photoaged skin, wrinkles result from an increased degradation and a decreased de novo synthesis of collagen fibers. At the molecular level, photoaged skin is characterized by increased amounts of large-scale deletions of the mitochondrial (mt) genome such as the 4,977 bp common deletion. The common deletion can be generated in dermal fibroblasts through repetitive ultraviolet (UV) A irradiation, and this was found to be associated with an increased expression of the collagen-degrading enzyme… CONTINUE READING