Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61.

@article{McNeill2007PartialDO,
  title={Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61.},
  author={Alexandra R McNeill and Evelyn Spittle and B. Thomas B{\"a}ckstr{\"o}m},
  journal={Scandinavian journal of immunology},
  year={2007},
  volume={65 1},
  pages={63-9}
}
The role CD4(+) CD25(+) regulatory T cells (Treg) play in modulating the immune response has been investigated extensively over recent years. Much of the work to date has used the activation marker CD25 to define, enrich and deplete Treg. However, the identification of FoxP3 as a definitive marker of Treg has allowed us to study the effect of monoclonal antibodies against CD25 on regulatory T-cell populations. Recently, published data have indicated that Treg are inactivated, not depleted… CONTINUE READING