Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice.

@article{Baba2016PartialDO,
  title={Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice.},
  author={Itsuko Baba and Yasuhiro Egi and Kazuo Suzuki},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 1},
  pages={231-6}
}
Renal fibrosis is a well‑known cause for the progression of chronic kidney disease. Rho/Rho‑associated coiled‑coil kinase (ROCK) signaling is involved in renal fibrotic processes. Non‑selective ROCK1/2 inhibitors have been reported to reduce renal interstitial fibrosis in a rodent unilateral ureteral obstruction (UUO) model. To clarify the role and… CONTINUE READING