Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis.

@article{Andreassen2000PartialDO,
  title={Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis.},
  author={Ole A. Andreassen and Robert Ferrante and P{\'e}ter Kliv{\'e}nyi and Autumn M. Klein and Leslie A. Shinobu and Charles J. Epstein and Myron Flint Beal},
  journal={Annals of neurology},
  year={2000},
  volume={47 4},
  pages={447-55}
}
The pathogenesis of neuronal cell death as a consequence of mutations in copper/zinc superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis may involve oxidative damage and mitochondrial dysfunction. We examined whether crossing transgenic mice with the G93A SOD1 mutation with transgenic mice with a partial depletion of manganese… CONTINUE READING