Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects.

@article{Barrios1996PartialCO,
  title={Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects.},
  author={Claudio Barrios and Christine Brandt and Michael Berney and Paul Henri Lambert and Claire Anne Siegrist},
  journal={European journal of immunology},
  year={1996},
  volume={26 11},
  pages={2666-70}
}
We have recently shown that neonatal responses to a pannel of vaccine antigens and presentation systems differed qualitatively from adult responses by a bias towards a TH2 pattern. Here we report that a selected adjuvant comprising block copolymers in a water-in-oil emulsion can induce balanced TH1/TH2 responses in BALB/c mice primed at 1 week of age with an immunodominant tetanus peptide vaccine. However, using this specific TH1-driving adjuvant only at time of boosting was not sufficient to… CONTINUE READING