Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors.

@article{Fleming2005PartialCO,
  title={Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors.},
  author={J Fleming and Afroditi Spinoulas and Maolin Zheng and Sharon Cunningham and Samantha L. Ginn and Robert C McQuilty and Peter B. Rowe and Ian E. Alexander},
  journal={Human gene therapy},
  year={2005},
  volume={16 8},
  pages={947-56}
}
Peripheral nervous system (PNS) sensory neurons are directly involved in the pathophysiology of a number of debilitating inherited and acquired neurological conditions. The lack of effective treatments for many such conditions provides a strong rationale for exploring novel therapeutic approaches, including gene therapy. Friedreich ataxia (FRDA), a sensory neuropathy, is a progressive neurodegenerative disease associated with a loss of large sensory neurons from the dorsal root ganglia. Because… CONTINUE READING

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