Partial characterization of a novel 'GGA' factor which binds to the osteonectin promoter in bovine bone cells.

@article{Ibaraki1993PartialCO,
  title={Partial characterization of a novel 'GGA' factor which binds to the osteonectin promoter in bovine bone cells.},
  author={K. Ibaraki and Pamela Robey and Marian Frances Young},
  journal={Gene},
  year={1993},
  volume={130 2},
  pages={225-32}
}
Osteonectin (On)/SPARC (secreted protein, acidic and rich in cysteine) is a highly conserved extracellular matrix protein found in bone and other tissues throughout vertebrate evolution. In previous studies, approximately 500 bp of DNA 5' to the transcription start point (tsp) and a part of exon 1, including homopurine (Rn)/homopyrimidine (Yn)-rich sequences (the 'GGA box' and its complements), was demonstrated to be important in upregulation of On gene expression in a cell-specific manner. The… CONTINUE READING