Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to rhesus macaques.

@article{Verma2012PartialBA,
  title={Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to rhesus macaques.},
  author={Rahul Kumar Verma and Jatinder Kaur Mukker and Ravi Shankar Singh and Kaushlendra Kumar and Priya Ranjan Prasad Verma and Amit Misra},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 4},
  pages={1011-6}
}
Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5, or 25 mg of each drug were administered daily for 90 days to rhesus macaques (n = 4/group). Single inhalations or intravenous (i.v.) doses were administered to separate groups. Drugs in serum, alveolar macrophages, and organ homogenates were assayed by high-performance liquid chromatography (HPLC… CONTINUE READING