Partial agonists of benzodiazepine receptors for the treatment of epilepsy, sleep, and anxiety disorders.

Abstract

The classic benzodiazepines produce anxiolytic, anticonvulsant, sedative and myorelaxant effects at overlapping dose ranges. Efforts to reduce the sedative/myorelaxant component of this profile has a long history. Two rational approaches might theoretically lead to the desired drugs. One is based on the combination of partial (low efficacy) agonists of the… (More)

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