Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays.

@article{JastrzbskaWisek2013PartialAE,
  title={Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays.},
  author={Magdalena Jastrzębska-Więsek and Agata Siwek and Grzegorz Kazek and Barbara Nawieśniak and A Sturzenegger Partyka and Monika Marcinkowska and Marcin Kołaczkowski and Anna Wesołowska},
  journal={Pharmacological reports : PR},
  year={2013},
  volume={65 4},
  pages={
          998-1005
        }
}
BACKGROUND Over recent years, the 5-hydroxytryptamine6 (5-HT6) receptor has emerged as a promising molecular target which interacts with several central nervous system acting drugs. In animal models, both agonists and antagonists of this receptor exhibit equivalent potency and efficacy as potential antidepressants, anxiolytics and anti-obesity or anti-dementia drugs. EMD386088 (5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride) has been described as a high affinity 5… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Potentail role of the 5 - HT 6 receptor in depression and anxiety : an overview of preclinical data

  • A Weso3owska, M Jastrzêbska-Wiêsek
  • Pharmacol Rep
  • 2010

Effect of ST1936, a 5-HT6 ligand, on rodent adenylate cyclase and forced swimming test

  • F Borsini, MA Stasi, P Minetti, T Riccioni, T Mennini
  • Abstract book of CINP Biennial International…
  • 2008
2 Excerpts

Similar Papers

Loading similar papers…