Partial agonism at the α7 nicotinic acetylcholine receptor improves attention, impulsive action and vigilance in low attentive rats.

@article{Hayward2017PartialAA,
  title={Partial agonism at the α7 nicotinic acetylcholine receptor improves attention, impulsive action and vigilance in low attentive rats.},
  author={Andrew Hayward and Lisa Adamson and Joanna C. Neill},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2017},
  volume={27 4},
  pages={325-335}
}
Inattention is a disabling symptom in conditions such as schizophrenia and attention deficit/hyperactivity disorder. Nicotine can improve attention and vigilance, but is unsuitable for clinical use due to abuse liability. Genetic knockout of the α7 nicotinic acetylcholine receptor (nAChR) induces attention deficits therefore selective agonism may improve attention, without the abuse liability associated with nicotine. The α7 nAChR partial agonist encenicline (formerly EVP-6124) enhances memory… CONTINUE READING
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