Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis.

@article{Tudur2014PartialAO,
  title={Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis.},
  author={Eva Tudur{\'i} and Heather Courtney Denroche and J Anlauf‐Dunn Kara and Ali Asadi and Jessica K. Fox and Timothy J Kieffer},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={306 7},
  pages={
          E748-55
        }
}
The role of glucagon in the pathological condition of diabetes is gaining interest, and it has been recently reported that its action is essential for hyperglycemia to occur. Glucagon levels, which are elevated in some diabetic models, are reduced following leptin therapy. Likewise, hyperglycemia is corrected in type 1 diabetic mice treated with leptin, although the mechanisms have not been fully determined. A direct inhibitory effect of leptin on mouse and human α-cells has been demonstrated… CONTINUE READING

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Glucagon - the new 'insulin' in the pathophysiology of diabetes.

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