Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

@article{Satapati2008PartialRT,
  title={Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism},
  author={Santhosh Satapati and Tianteng He and Takeshi Inagaki and Matthew J Potthoff and Matthew E Merritt and V. Esser and David J Mangelsdorf and Steven A. Kliewer and Jeffrey D. Browning and Shawn C. Burgess},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2012 - 2021}
}
OBJECTIVE Fluxes through mitochondrial pathways are defective in insulin-resistant skeletal muscle, but it is unclear whether similar mitochondrial defects play a role in the liver during insulin resistance and/or diabetes. The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes. RESEARCH DESIGN AND METHODS Mitochondrial fluxes were measured using (2)H/(13)C tracers and… CONTINUE READING

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