Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.

@article{Ginkel1999PartialIW,
  title={Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.},
  author={Frederik W. van Ginkel and Sharon M. Wahl and John F Kearney and Mi Na Kweon and Kohtaro Fujihashi and Peter D. Burrows and Hiroshi Kiyono and Jerry R. Mcghee},
  journal={Journal of immunology},
  year={1999},
  volume={163 4},
  pages={
          1951-7
        }
}
Though it has been shown that TGF-beta 1 directs B cells to switch to IgA in vitro, no studies have assessed TGF-beta 1 effects on mucosal vs systemic immunity in vivo. When the B cell functions of TGF-beta 1 gene-disrupted (TGF-beta 1-/-) mice were analyzed, significantly decreased IgA levels and increased IgG and IgM levels in serum and external secretions were observed. Further, analysis of Ab forming cells (AFC) isolated from both mucosal and systemic lymphoid tissue showed elevated IgM… CONTINUE READING

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