Corpus ID: 81067606

Partial Characterization of Carbohydrate Residues of Serum Glycoproteins in Neoplastic Disease

  title={Partial Characterization of Carbohydrate Residues of Serum Glycoproteins in Neoplastic Disease},
  author={P. Sobocinski and K. Hartley and A. S. Evans and W. J. Canterbury},
Abstract : The objective of this investigation was primarily to establish that the apparent increase in serum fucose levels in patients with malignant tumors is real and to obtain data as to its source. Carbohydrate residues (L-fucose, D-mannose, D-galactose) were estimated by borate ion-exchange chromatography after mild acid hydrolysis of serum proteins. Data are presented which confirm reported increases in levels of serum fucose in certain malignancies and indicate that these increases may… Expand
3 Citations
Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.
Summary The method used permits correction for the influence of the neutral hexoses, galactose and mannose, on the apparent concentration of protein-bound l-fucose, as estimated by theExpand
Liquid-chromatographic analysis for neutral carbohydrates in serum glycoproteins.
A sensitive, reproducible procedure of analysis for the six neutral carbohydrates in glycoproteins, by high-resolution anion-exchange chromatography is described, and results are presented for mannose, fucose, and galactose in serum glycoproteinins for both normal women and those with metastatic breast cancer. Expand
Chronic Depression of Serum Sialic Acid Levels in Alloxan-Induced Diabetes
Results indicate that in the uncompensated diabetic animal a chronic depression of serum sialic acid level occurs with no apparent alteration in the level of L-fucose, and fails to confirm the increased protein-bound fucose levels reported in human diabetics. Expand