Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1β Responses.

Abstract

UNLABELLED The small hydrophobic (SH) gene of respiratory syncytial virus (RSV), a major cause of infant hospitalization, encodes a viroporin of unknown function. SH gene knockout virus (RSV ΔSH) is partially attenuated in vivo, but not in vitro, suggesting that the SH protein may have an immunomodulatory role. RSV ΔSH has been tested as a live attenuated… (More)
DOI: 10.1128/JVI.01070-15

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@article{Russell2015PartialAO, title={Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1β Responses.}, author={Ryan F Russell and Jacqueline U. McDonald and Maria Ivanova and Ziyun Zhong and Alexander Bukreyev and John S Tregoning}, journal={Journal of virology}, year={2015}, volume={89 17}, pages={8974-81} }