Corpus ID: 197633109

Parthenolide induces apoptosis and inhibits proliferation of human 786-O kidney cancer cells in vitro

  title={Parthenolide induces apoptosis and inhibits proliferation of human 786-O kidney cancer cells in vitro},
  author={Li Dong and W. Shi and Wei-hua Li and Yuan Li and Yan-qin Sun},
Background: Clear cell renal carcinoma is one of the most common malignant tumors, with high incidence and mortality rates. Prognosis of RCC is poor, with 5-year survival rates less than 5%. PTL, a naturally occurring sesquiterpene lactone isolated from Tanacetum parthenium, can inhibit tumor cell growth and induce tumor cell apoptosis. Methods: MTT and apoptosis assays were performed to evaluate the function of PTL on human 786-O kidney cancer cells. Moreover, Western blotting analysis was… Expand
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