Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis*

  title={Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis*},
  author={M. Sheehan and H. Wong and P. Hake and B. Zingarelli},
  journal={Critical Care Medicine},
  • M. Sheehan, H. Wong, +1 author B. Zingarelli
  • Published 2003
  • Medicine
  • Critical Care Medicine
  • ObjectiveNuclear factor (NF)-&kgr;B is a transcriptional factor required for the gene expression of many inflammatory mediators. This study was designed to investigate the biological effects of parthenolide, a specific inhibitor of NF-&kgr;B activation, in experimental sepsis and multiple organ failure. DesignProspective, randomized laboratory investigation that used an established model of cecal ligation and puncture to induce polymicrobial sepsis in rats. SettingUniversity hospital laboratory… CONTINUE READING
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