Parthenolide Inhibits the LPS‐induced Secretion of IL‐6 and TNF‐α and NF‐κB Nuclear Translocation in BV‐2 Microglia

  title={Parthenolide Inhibits the LPS‐induced Secretion of IL‐6 and TNF‐α and NF‐κB Nuclear Translocation in BV‐2 Microglia},
  author={P. Magni and M. Ruscica and E. Dozio and Eleonora Rizzi and G. Beretta and Roberto Maffei Facino},
  journal={Phytotherapy Research},
  • P. Magni, M. Ruscica, +3 authors Roberto Maffei Facino
  • Published 2012
  • Medicine
  • Phytotherapy Research
  • Feverfew (Tanacetum parthenium [L.] Sch. Bip. [Asteraceae]) is a popular herbal treatment used to prevent and treat headache and migraine. Parthenolide (PTN), the sesquiterpene lactonic derivative that is the plant's major component, might be one of the ingredients that act on mediators of inflammation. In the present study, in cultured lipopolysaccharide (LPS)‐stimulated BV‐2 microglia pretreatment with PTN caused a dose‐dependent reduction of interleukin‐6 (IL‐6) secretion (29% by 200 nm, p… CONTINUE READING
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