Parthenogenetic activation of oocytes in c-mos-deficient mice

  title={Parthenogenetic activation of oocytes in c-mos-deficient mice},
  author={Naohiro Hashimoto and Nobumoto Watanabe and Yasuhide Furuta and Hiroyuki Tamemoto and Noriyuiki Sagata and Minesuke Yokoyama and Kenji Okazaki and Mariko Nagayoshi and Naoki Takeda and Yoji Ikawa and Shinichi Aizawa},
IN Xenopus the c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation1, for the progression from meiosis I to meiosis II2,3 and for the second meiotic metaphase arrest, acting as an essential component of the cytostatic factor CSF4,5. Its function in mouse oocytes is unclear6–9, however, as is the biological significance of c-mos mRNA expression in testes1,10 and several somatic tissues1,10,11. We have generated c-mos-deficient mice by gene targeting in… CONTINUE READING