Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults.

@article{Mastrangelo2000PartIO,
  title={Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults.},
  author={Alison J. Mastrangelo and J Marie Hardwick and Shaobo Zou and Michael J. Betenbaugh},
  journal={Biotechnology and bioengineering},
  year={2000},
  volume={67 5},
  pages={
          555-64
        }
}
A number of bioreactor configurations have been developed for the manufacture of products from mammalian cell hosts. Even in the most efficient of these, however, problems such as nutrient exhaustion, growth factor deprivation, and toxin accumulations may arise. Consequently, the current effort focused on the feasibility of overexpressing anti-apoptosis genes in baby hamster kidney (BHK) and Chinese hamster ovary (CHO) cells as a means of limiting cell death upon exposure to three such insults… CONTINUE READING
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