Part I—mechanism of adaptation: high nitric oxide adapted A549 cells show enhanced DNA damage response and activation of antiapoptotic pathways

@article{Aqil2013PartIO,
  title={Part I—mechanism of adaptation: high nitric oxide adapted A549 cells show enhanced DNA damage response and activation of antiapoptotic pathways},
  author={Madeeha Aqil and Kim M. Elseth and Benjamin J. Vesper and Zane Deliu and Bulent Aydogan and Jiaping Xue and James A. Radosevich},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={2403-2415}
}
Our previous studies demonstrate that A549, a human lung adenocarcinoma line, could be adapted to the free radical nitric oxide (NO●). NO● has been shown to be overexpressed in human tumors. The original cell line, A549 (parent), and the newly adapted A549-HNO (which has a more aggressive phenotype) serves as a useful model system to study the role of NO… CONTINUE READING