Parsing the effects of individual SNPs in candidate genes with family data.

@article{Hoffmann2010ParsingTE,
  title={Parsing the effects of individual SNPs in candidate genes with family data.},
  author={Thomas J. Hoffmann and Christoph Lange and Stijn Vansteelandt and Benjamin A. Raby and Dawn L. DeMeo and Edwin K. Silverman and Scott T. Weiss and Nan M. Laird},
  journal={Human heredity},
  year={2010},
  volume={69 2},
  pages={91-103}
}
We introduce a stepwise approach for family-based designs for selecting a set of markers in a gene that are independently associated with the disease. The approach is based on testing the effect of a set of markers conditional on another set of markers. Several likelihood-based approaches have been proposed for special cases, but no model-free based tests… CONTINUE READING