Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation

@inproceedings{Dhliwayo2014ParpIP,
  title={Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation},
  author={Nyembezi Dhliwayo and Michael P. Sarras and Ernest Luczkowski and Samantha M. Mason and Robert V. Intine},
  booktitle={Diabetes},
  year={2014}
}
Studies from human cells, rats, and zebrafish have documented that hyperglycemia (HG) induces the demethylation of specific cytosines throughout the genome. We previously documented that a subset of these changes become permanent and may provide, in part, a mechanism for the persistence of complications referred to as the metabolic memory phenomenon. In this report, we present studies aimed at elucidating the molecular machinery that is responsible for the HG-induced DNA demethylation observed… CONTINUE READING
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