Paroxysmal nocturnal hemoglobinuria with onset in childhood and adolescence.

  title={Paroxysmal nocturnal hemoglobinuria with onset in childhood and adolescence.},
  author={Russell E Ware and Susan E. H. Hall and Wendell F. Rosse},
  journal={The New England journal of medicine},
  volume={325 14},
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder characterized by hemoglobinuria, thrombosis, infection, and a tendency toward bone marrow aplasia. Onset usually occurs in adulthood. Few children and adolescents with PNH have been described, and data on diagnosis, clinical course, and survival in young patients are unavailable. METHODS We retrospectively reviewed clinical and laboratory data on all patients 21 years old or younger in whom PNH had… CONTINUE READING


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