Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories.

  title={Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories.},
  author={R{\'e}gis Peffault de Latour and J. Y. Mary and C{\'e}lia Salanoubat and Louis Terriou and Gabriel Etienne and Mohamad Mohty and Sophie Roth and Sophie de Guibert and S{\'e}bastien Maury and Jean Yves Cahn and Gerard J Soci{\'e}},
  volume={112 8},
The natural history of paroxysmal nocturnal hemoglobinuria (PNH) clinical subcategories (classic PNH and aplastic anemia [AA]/PNH syndrome) is still unknown. We retrospectively studied 460 PNH patients diagnosed in 58 French hematologic centers from 1950 to 2005. The median (SE) follow-up time was 6.8 (0.5) years. The median survival time (SE) was 22 (2.5) years. We identified 113 patients with classic PNH, 224 patients with AA-PNH syndrome, and 93 (22%) intermediate patients who did not fit… CONTINUE READING
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