Paroxetine in the treatment of elderly depressed patients in general practice: a double-blind comparison with amitriptyline.

@article{Hutchinson1992ParoxetineIT,
  title={Paroxetine in the treatment of elderly depressed patients in general practice: a double-blind comparison with amitriptyline.},
  author={David Rn Hutchinson and Shidong Tong and Chauncey Alson Moon and Margaret A. Vince and Anthony A. Clarke},
  journal={International clinical psychopharmacology},
  year={1992},
  volume={6 Suppl 4},
  pages={
          43-51
        }
}
A total of 101 patients entered a double-blind, parallel-group study in general practice, comparing the efficacy and tolerability of paroxetine and amitriptyline in elderly depressed patients. All patients received placebo for 1 week followed by active therapy for a total of 6 weeks. Medication was randomly allocated, two-thirds of the patients took paroxetine (20 mg daily) and one-third received amitriptyline (50 mg daily); this dose was increased to 30 mg and 100 mg, respectively, after 1… CONTINUE READING
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Pharmacotherapy of affective disorders in old age.

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