Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats.


Accumulating evidences have shown that diabetes is often accompanied with depression, thus it is possible that oral antidiabetic agent glyburide and antidepressive agent paroxetine are co-administered in diabetic patients. The aim of this study was to assess interactions between glyburide and paroxetine in rats. Effect of paroxetine on pharmacokinetics of… (More)
DOI: 10.1016/j.dmpk.2015.02.004


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