Paroxetine: current status in psychiatry

@article{Pae2007ParoxetineCS,
  title={Paroxetine: current status in psychiatry},
  author={Chi-Un Pae and Ashwin A Patkar},
  journal={Expert Review of Neurotherapeutics},
  year={2007},
  volume={7},
  pages={107 - 120}
}
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. It is commercially available in both an immediate-release (paroxetine) and a controlled-release formulation (paroxetine CR). The latter product was developed to improve gastrointestinal tolerability. Paroxetine is the most potent inhibitor of the reuptake of serotonin among the available SSRIs. It has approved indications for the treatment of major depression, obsessive–compulsive… Expand
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41 Citations
Background Citations
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Results Citations
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41 Citations

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Citation Type

Paroxetine: safety and tolerability issues
TLDR
Whether the tolerability profile of paroxetine differs substantially from other new antidepressants (including other SSRIs) needs to be determined in adequately powered well-designed randomised controlled comparative clinical trials. Expand
Extended-release formulation of venlafaxine in the treatment of post-traumatic stress disorder
TLDR
A review of the potential role of venlafaxine XR in the treatment of PTSD, based on currently available evidence, finds that it has not been extensively studied for PTSD, compared with other anxiety disorders. Expand
Paroxetine—Overview of the Molecular Mechanisms of Action
TLDR
The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. Expand
A comparative review of escitalopram, paroxetine, and sertraline: are they all alike?
TLDR
Overall, as an allosteric serotonin reuptake inhibitor that is somewhat different from classical SSRIs, escitalopram is the first choice judged by combined efficacy and tolerability, and nonclinical data have offered possible mechanisms through which escITALopram could be more efficacious. Expand
Review: Problems associated with long-term treatment with selective serotonin reuptake inhibitors
Although the selective serotonin reuptake inhibitors (SSRIs), which are now widely used as a first-line treatment for depression and many other psychiatric conditions, are generally well tolerated,… Expand
CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine.
TLDR
Genetic variants in the CYP1A2 region may be indicators of treatment response in MDD patients to paroxetine. Expand
Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers.
TLDR
Citalopram reduced attentional vigilance towards fearful faces but did not affect the interpretation of ambiguous homographs as threatening, which supports a growing literature suggesting that an important mechanism through which pharmacological agents may exert their effects on mood is by reversing the cognitive biases that characterize the disorders that they treat. Expand
Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: a randomized controlled trial.
TLDR
Initial treatment with paroxetine plus prolonged exposure was more efficacious than prolonged exposure plus placebo for PTSD related to the World Trade Center attack. Expand
Effect of comedication of bupropion and other antidepressants on body mass index
TLDR
This study reports an adverse weight gain on co-medication of escitalopram and bupropion, which warrants further validation studies, as considering co- medication effects of antidepressants on weight is important to design robust depression treatment plans. Expand
Antidepressant treatment of premature ejaculation: discontinuation rates and prevalence of side effects for dapoxetine and paroxetine in a naturalistic setting
TLDR
Investigation of prevalence of and reasons for selective serotonin reuptake inhibitor (SSRI) discontinuation and compare the two most common SSRIs used in premature ejaculation (PE) treatment, in naturalistic settings confirmed paroxetine was more effective and better tolerated than dapoxetines. Expand
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References

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TLDR
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The efficacy seen in short-term studies with paroxetine in the treatment of depression is maintained when the drug is given chronically, and the compound shows efficacy superior to placebo, and similar to that obtained with standard tricyclic or tetracyclic agents. Expand
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TLDR
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