Parotid carcinoma: expression of kit protein and epidermal growth factor receptor.

Abstract

OBJECTIVES Our aim is to investigate the expression of kit protein (KIT) and epidermal growth factor receptor (EGFR) in parotid carcinomas in order to correlate the expression to histology and prognosis. Further we want to perform mutation analysis of KIT-positive adenoid cystic carcinomas. PATIENTS AND METHODS Formalin-fixed paraffin-embedded sections from 73 patients with parotid gland carcinomas were used for the study. The sections were stained with both KIT and EGFR polyclonal antibodies. Twelve KIT-positive adenoid cystic carcinomas were examined for c-kit mutation in codon 816. RESULTS Of all carcinomas 25% were KIT-positive and 79% were EGFR-positive. Ninety-two percentage of the adenoid cystic carcinomas were KIT-positive. None of the adenoid cystic carcinomas had mutations in codon 816 of the c-kit gene. CONCLUSION Neither KIT- nor EGFR-expression seem to harbour significant prognostic information. Adenoid cystic carcinomas express KIT, but no mutations in codon 816 of the c-kit gene were identified.

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@article{Srensen2006ParotidCE, title={Parotid carcinoma: expression of kit protein and epidermal growth factor receptor.}, author={Kristine Bj\orndal S\orensen and Christian Godballe and Karin de Stricker and Annelise Solveig Krogdahl}, journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology}, year={2006}, volume={35 5}, pages={286-91} }