Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil.

  title={Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil.},
  author={St{\'e}phane Thobois and Eug{\'e}nie Lhomm{\'e}e and H{\'e}l{\`e}ne Klinger and Claire Ardouin and Emmanuelle Schmitt and Am{\'e}lie Bichon and Andrea Kistner and Anna Castrioto and Jing Xie and Val{\'e}rie Fraix and Pierre P{\'e}lissier and St{\'e}phan Chabard{\`e}s and P. B. A. Mertens and J. Diego Quesada and Jean-Luc Bosson and Pierre Pollak and Emmanuel Broussolle and Paul Krack},
  journal={Brain : a journal of neurology},
  volume={136 Pt 5},
Apathy is one of the most common symptoms encountered in Parkinson's disease, and is defined as a lack of motivation accompanied by reduced goal-directed cognition, behaviour and emotional involvement. In a previous study we have described a delayed withdrawal syndrome after successful motor improvement related to subthalamic stimulation allowing for a major decrease in dopaminergic treatment. This withdrawal syndrome correlated with a diffuse mesolimbic dopaminergic denervation. To confirm our… CONTINUE READING
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